5VV4

Structure of human neuronal nitric oxide synthase heme domain in complex with 4-(2-(((2-Aminoquinolin-7-yl)methyl)amino)ethyl)-2-methylbenzonitrile

Summary for 5VV4

Entry DOI	10.2210/pdb5vv4/pdb
Related	5VUI 5VUJ 5VUK 5VUL 5VUM 5VUN 5VUO 5VUP 5VUQ 5VUR 5VUS 5VUT 5VUU 5VUV 5VUW 5VUX 5VUY 5VUZ 5VV0 5VV1 5VV2 5VV3 5VV5 5VV6 5VV7 5VV8 5VV9 5VVA 5VVB 5VVC 5VVD 5VVG 5VVN
Descriptor	Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
Functional Keywords	nitric oxide synthase, inhibitor complex, heme enzyme, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	99982.67
Authors	Huiying, L.,Thomas, L.P. (deposition date: 2017-05-19, release date: 2017-08-23, Last modification date: 2023-10-04)
Primary citation	Pensa, A.V.,Cinelli, M.A.,Li, H.,Chreifi, G.,Mukherjee, P.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors. J. Med. Chem., 60:7146-7165, 2017 Cited by PubMed: 28776992 DOI: 10.1021/acs.jmedchem.7b00835 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation