5VLK

Short PCSK9 delta-P' complex with shrunken peptide bearing homo-Arginine

Summary for 5VLK

Entry DOI	10.2210/pdb5vlk/pdb
Related	5VL7 5VLA 5VLH 5VLL 5VLP
Descriptor	Proprotein convertase subtilisin/kexin type 9, ACE-THR-VAL-PHE-THR-SER-TRP-GLU-GLU-TYR-LEU-ASP-TRP-VAL-NH2 peptide, ACE-TRP-ASN-LEU-VAL-HRG-ILE-GLY-LEU-LEU peptide, ... (5 entities in total)
Functional Keywords	proprotein convertase, subtilisin, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	52803.65
Authors	Eigenbrot, C.,Ultsch, M. (deposition date: 2017-04-25, release date: 2017-08-16, Last modification date: 2023-11-15)
Primary citation	Zhang, Y.,Ultsch, M.,Skelton, N.J.,Burdick, D.J.,Beresini, M.H.,Li, W.,Kong-Beltran, M.,Peterson, A.,Quinn, J.,Chiu, C.,Wu, Y.,Shia, S.,Moran, P.,Di Lello, P.,Eigenbrot, C.,Kirchhofer, D. Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. Nat. Struct. Mol. Biol., 24:848-856, 2017 Cited by PubMed: 28825733 DOI: 10.1038/nsmb.3453 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation