5VK0
Crystal structure of human MDM2 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI
Summary for 5VK0
Entry DOI | 10.2210/pdb5vk0/pdb |
Related | 3EQS 5VK1 |
Descriptor | E3 ubiquitin-protein ligase Mdm2, Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | mdm2-peptide inhibitor complex, oncoprotein, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation pathway, zinc-finger, stapled peptide, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 24 |
Total formula weight | 138823.07 |
Authors | Tolbert, W.D.,Gohain, N.,Pazgier, M. (deposition date: 2017-04-20, release date: 2018-04-25, Last modification date: 2024-07-10) |
Primary citation | Li, X.,Tolbert, W.D.,Hu, H.G.,Gohain, N.,Zou, Y.,Niu, F.,He, W.X.,Yuan, W.,Su, J.C.,Pazgier, M.,Lu, W. Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design. Chem Sci, 10:1522-1530, 2019 Cited by PubMed: 30809370DOI: 10.1039/c8sc03275k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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