5VK0

Crystal structure of human MDM2 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI

5VK0 の概要

• エントリーDOI: 10.2210/pdb5vk0/pdb
• 関連するPDBエントリー: 3EQS 5VK1
• 分子名称: E3 ubiquitin-protein ligase Mdm2, Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: mdm2-peptide inhibitor complex, oncoprotein, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation pathway, zinc-finger, stapled peptide, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 24
• 化学式量合計: 138823.07

構造登録者

Tolbert, W.D.,Gohain, N.,Pazgier, M. (登録日: 2017-04-20, 公開日: 2018-04-25, 最終更新日: 2023-10-04)

• 主引用文献: Li, X.,Tolbert, W.D.,Hu, H.G.,Gohain, N.,Zou, Y.,Niu, F.,He, W.X.,Yuan, W.,Su, J.C.,Pazgier, M.,Lu, W.; Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design.; Chem Sci, 10:1522-1530, 2019; PubMed: 30809370; DOI: 10.1039/c8sc03275k

実験手法

X-RAY DIFFRACTION (1.8 Å)