5VJ3

HIV Protease (PR) in open form with Mg2+ in active site and HIVE-9 in eye site

Summary for 5VJ3

• Entry DOI: 10.2210/pdb5vj3/pdb
• Related: 5TO9
• Descriptor: Protease, 4-methyl-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}carbamoyl)benzene-1-sulfonamide, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: protease, allostery, fragment binding, eye site, hydrolase
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 1
• Total formula weight: 11235.45

Authors

Tiefenbrunn, T.,Stout, C.D. (deposition date: 2017-04-18, release date: 2018-04-18, Last modification date: 2023-10-04)

• Primary citation: Forli, S.,Tiefenbrunn, T.,Baksh, M.M.,Chang, M.W.,Perryman, A.,Garg, D.,Happer, M.,Lin, Y.-C.,Goodsell, D.,Angelina, E.L.,De Vera, I.,Kojetin, D.,Torbett, B.E.,Finn, M.G.,Elder, J.,Stout, C.D.,Olson, A.; Fragment-based campaign for the identification of potential exosite binders of HIV-1 Protease; to be published,

Experimental method

X-RAY DIFFRACTION (2 Å)