5VJ3

HIV Protease (PR) in open form with Mg2+ in active site and HIVE-9 in eye site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue HV9 A 1101

Chain	Residue
A	VAL1032
A	THR1080
A	PRO1081
A	HOH1206
A	HOH1224
A	VAL1032
A	ILE1047
A	ILE1050
A	ILE1054
A	VAL1056
A	GLN1061
A	PRO1079
A	THR1080

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site_id	AC2
Number of Residues	12
Details	binding site for residue MG A 1102

Chain	Residue
A	HOH1207
A	HOH1207
A	HOH1209
A	HOH1209
A	HOH1212
A	HOH1212
A	HOH1224
A	HOH1224
A	HOH1227
A	HOH1227
A	HOH1233
A	HOH1233

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI

Chain	Residue	Details
A	ALA1022-ILE1033

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094

Chain	Residue	Details
A	ASP1025

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by viral protease => ECO:0000250

Chain	Residue	Details
A	PHE1099

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