5VJ3
HIV Protease (PR) in open form with Mg2+ in active site and HIVE-9 in eye site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protease | polymer | 99 | 10767.7 | 1 | UniProt (Q8Q8V9) Pfam (PF00077) UniProt (by SIFTS) (P12497) | Human immunodeficiency virus 1 | |
| 2 | B (A) | 4-methyl-N-({1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidin-4-yl}carbamoyl)benzene-1-sulfonamide | non-polymer | 443.4 | 1 | Chemie (HV9) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A: 1001 - 1099 (UniProt: Q8Q8V9)
| PDB | External Database | Details |
|---|---|---|
| Lys 1007 | Gln 10 | conflict |
| Ile 1033 | Leu 36 | conflict |
| Ile 1063 | Pro 66 | conflict |
| Ala 1067 | Cys 70 | conflict |
| Ala 1095 | Cys 98 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 10767.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 467.7 | |
| All* | Total formula weight | 11235.4 |
