5VDK

Crystal structure of human WEE2 kinase domain in complex with MK1775

5VDK の概要

• エントリーDOI: 10.2210/pdb5vdk/pdb
• 関連するPDBエントリー: 5VC3 5VC4 5VC5 5VC6 5VD2 5VD4 5VD5 5VD7 5VD8 5VD9 5VDA
• 分子名称: Wee1-like protein kinase 2, 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: kinase domain, cell cycle, wee2, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33856.75

構造登録者

Zhu, J.-Y.,Schonbrunn, E. (登録日: 2017-04-03, 公開日: 2017-08-23, 最終更新日: 2023-10-04)

• 主引用文献: Zhu, J.Y.,Cuellar, R.A.,Berndt, N.,Lee, H.E.,Olesen, S.H.,Martin, M.P.,Jensen, J.T.,Georg, G.I.,Schonbrunn, E.; Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.; J. Med. Chem., 60:7863-7875, 2017; PubMed: 28792760; DOI: 10.1021/acs.jmedchem.7b00996

実験手法

X-RAY DIFFRACTION (2.7 Å)