5VDK
Crystal structure of human WEE2 kinase domain in complex with MK1775
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Wee1-like protein kinase 2 | polymer | 297 | 33071.2 | 1 | UniProt (P0C1S8) Pfam (PF00069) In PDB | Homo sapiens (Human) | Wee1-like protein kinase 1B,Wee1B kinase |
| 2 | A | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one | non-polymer | 500.6 | 1 | Chemie (8X7) | |||
| 3 | A | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 4 | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A: 202 - 492 (UniProt: P0C1S8)
| PDB | External Database | Details |
|---|---|---|
| Gly 196 | - | expression tag |
| Pro 197 | - | expression tag |
| Glu 198 | - | expression tag |
| Phe 199 | - | expression tag |
| Gly 200 | - | expression tag |
| Ser 201 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33071.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 785.5 | |
| All* | Total formula weight | 33856.8 |
