5VBZ
Crystal Structure of Small Molecule Disulfide 2C07 Bound to H-Ras M72C GppNHp
Summary for 5VBZ
Entry DOI | 10.2210/pdb5vbz/pdb |
Descriptor | GTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | gtpase, inhibitor, gdp, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane. Isoform 2: Nucleus: P01112 |
Total number of polymer chains | 3 |
Total formula weight | 59750.65 |
Authors | Gentile, D.R.,Jenkins, M.L.,Moss, S.M.,Burke, J.E.,Shokat, K.M. (deposition date: 2017-03-30, release date: 2017-10-25, Last modification date: 2023-10-04) |
Primary citation | Gentile, D.R.,Rathinaswamy, M.K.,Jenkins, M.L.,Moss, S.M.,Siempelkamp, B.D.,Renslo, A.R.,Burke, J.E.,Shokat, K.M. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. Cell Chem Biol, 24:1455-1466.e14, 2017 Cited by PubMed: 29033317DOI: 10.1016/j.chembiol.2017.08.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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