5VB5

X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with an inverse agonist and SRC2 peptide

Summary for 5VB5

Entry DOI	10.2210/pdb5vb5/pdb
Related	5VB3 5VB6 5VB7
Descriptor	Nuclear receptor ROR-gamma, SRC2 chimera, SODIUM ION, N-[(2R)-3-(4-{[3-(4-chlorophenyl)propanoyl]amino}phenyl)-1-(4-methylpiperidin-1-yl)-1-oxopropan-2-yl]-4-methylpentanamide, ... (4 entities in total)
Functional Keywords	nuclear receptor, nuclear hormone receptor, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	32991.54
Authors	Li, X. (deposition date: 2017-03-28, release date: 2017-06-07, Last modification date: 2024-03-06)
Primary citation	Li, X.,Anderson, M.,Collin, D.,Muegge, I.,Wan, J.,Brennan, D.,Kugler, S.,Terenzio, D.,Kennedy, C.,Lin, S.,Labadia, M.E.,Cook, B.,Hughes, R.,Farrow, N.A. Structural studies unravel the active conformation of apo ROR gamma t nuclear receptor and a common inverse agonism of two diverse classes of ROR gamma t inhibitors. J. Biol. Chem., 292:11618-11630, 2017 Cited by PubMed: 28546429 DOI: 10.1074/jbc.M117.789024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.226 Å)

Structure validation