5VB5

X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with an inverse agonist and SRC2 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Nuclear receptor ROR-gamma, SRC2 chimera	polymer	280	32442.4	1	UniProt (P51449) Pfam (PF00104) UniProt (by SIFTS) (Q15596)	Homo sapiens (Human)	Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma,RORgt, RETINOID-RELATED ORPHAN RECEPTOR-GAMMA
2	B (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
3	C (A)	N-[(2R)-3-(4-{[3-(4-chlorophenyl)propanoyl]amino}phenyl)-1-(4-methylpiperidin-1-yl)-1-oxopropan-2-yl]-4-methylpentanamide	non-polymer		526.1	1	Chemie (92A)
4	D (A)	water	water		18.0	102	Chemie (HOH)

Sequence modifications

A: 260 - 507 (UniProt: P51449)

PDB	External Database	Details
Met 244	-	initiating methionine
Gly 245	-	expression tag
Ser 246	-	expression tag
Ser 247	-	expression tag
His 248	-	expression tag
His 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
Leu 254	-	expression tag
Val 255	-	expression tag
Pro 256	-	expression tag
Arg 257	-	expression tag
Gly 258	-	expression tag
Ser 259	-	expression tag

A: 508 - 523 (PDB: 5VB5)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	32442.4
Non-Polymers*	Number of molecules	2
	Total formula weight	549.1
All*	Total formula weight	32991.5

*Water molecules are not included.