5V7C

Crystal structure of LARP1-unique domain DM15 bound 5'TOP RNA sequence

Summary for 5V7C

• Entry DOI: 10.2210/pdb5v7c/pdb
• Related: 4ZC4 5V4R 5v87
• Descriptor: La-related protein 1, RNA (5'-R(*CP*UP*UP*UP*UP*CP*CP*G)-3') (3 entities in total)
• Functional Keywords: cap-binding, rna-binding, dm15, 5'top, rna binding protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : Q6PKG0
• Total number of polymer chains: 2
• Total formula weight: 22056.74

Authors

Berman, A.J.,Lahr, R.M.,Al-Ashtal, H.A. (deposition date: 2017-03-20, release date: 2017-04-19, Last modification date: 2023-10-04)

• Primary citation: Lahr, R.M.,Fonseca, B.D.,Ciotti, G.E.,Al-Ashtal, H.A.,Jia, J.J.,Niklaus, M.R.,Blagden, S.P.,Alain, T.,Berman, A.J.; La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs.; Elife, 6:-, 2017; PubMed: 28379136; DOI: 10.7554/eLife.24146

Experimental method

X-RAY DIFFRACTION (2.59 Å)