5V58

Crystal structure of human prolyl-tRNA synthetase in complex with Aze-SA

Summary for 5V58

• Entry DOI: 10.2210/pdb5v58/pdb
• Related: 5V59
• Descriptor: Bifunctional glutamate/proline--tRNA ligase, 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine, ZINC ION, ... (4 entities in total)
• Functional Keywords: ligase, aminoacyl-trna synthetase, non-proteinogenic amino acids
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 59558.27

Authors

Zhou, H.,Song, Y.,Schimmel, P. (deposition date: 2017-03-13, release date: 2018-01-10, Last modification date: 2023-10-04)

• Primary citation: Song, Y.,Zhou, H.,Vo, M.N.,Shi, Y.,Nawaz, M.H.,Vargas-Rodriguez, O.,Diedrich, J.K.,Yates, J.R.,Kishi, S.,Musier-Forsyth, K.,Schimmel, P.; Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid.; Nat Commun, 8:2281-2281, 2017; PubMed: 29273753; DOI: 10.1038/s41467-017-02201-z

Experimental method

X-RAY DIFFRACTION (2.59 Å)