5V21

Crystal structure of human SETD2 SET-domain in complex with H3K36M peptide and SAM

Summary for 5V21

• Entry DOI: 10.2210/pdb5v21/pdb
• Related: 5V22
• Descriptor: Histone-lysine N-methyltransferase SETD2, Histone H3K36M peptide, ZINC ION, ... (5 entities in total)
• Functional Keywords: methyltransferase, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 36604.76

Authors

Zhang, Y.,Tong, L. (deposition date: 2017-03-02, release date: 2017-03-22, Last modification date: 2023-10-04)

• Primary citation: Zhang, Y.,Shan, C.M.,Wang, J.,Bao, K.,Tong, L.,Jia, S.; Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation.; Sci Rep, 7:43906-43906, 2017; PubMed: 28256625; DOI: 10.1038/srep43906

Experimental method

X-RAY DIFFRACTION (2.415 Å)