5UXF

Crystal Structure of mouse RECON (AKR1C13) in complex with Cyclic di-AMP

Summary for 5UXF

Entry DOI	10.2210/pdb5uxf/pdb
Descriptor	Dihydrodiol dehydrogenase, (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide (3 entities in total)
Functional Keywords	cyclic di-amp, aldo-keto reductase, tim barrel, oxidoreductase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	39949.44
Authors	Luo, S.,Tong, L. (deposition date: 2017-02-22, release date: 2017-04-19, Last modification date: 2024-03-06)
Primary citation	McFarland, A.P.,Luo, S.,Ahmed-Qadri, F.,Zuck, M.,Thayer, E.F.,Goo, Y.A.,Hybiske, K.,Tong, L.,Woodward, J.J. Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-kappa B Activation and Shapes a Proinflammatory Antibacterial State. Immunity, 46:433-445, 2017 Cited by PubMed: 28329705 DOI: 10.1016/j.immuni.2017.02.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.501 Å)

Structure validation