5UXF

Crystal Structure of mouse RECON (AKR1C13) in complex with Cyclic di-AMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000253	molecular_function	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity
A	0001758	molecular_function	retinal dehydrogenase (NAD+) activity
A	0004032	molecular_function	aldose reductase (NADPH) activity
A	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
A	0004745	molecular_function	all-trans-retinol dehydrogenase (NAD+) activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0006693	biological_process	prostaglandin metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
A	0016491	molecular_function	oxidoreductase activity
A	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
A	0031406	molecular_function	carboxylic acid binding
A	0032052	molecular_function	bile acid binding
A	0033703	molecular_function	3-beta-hydroxy-5-beta-steroid dehydrogenase (NADP+) activity
A	0036130	molecular_function	prostaglandin H2 endoperoxidase reductase activity
A	0036131	molecular_function	prostaglandin D2 11-ketoreductase activity
A	0042448	biological_process	progesterone metabolic process
A	0044597	biological_process	daunorubicin metabolic process
A	0044598	biological_process	doxorubicin metabolic process
A	0045550	molecular_function	geranylgeranyl reductase activity
A	0045703	molecular_function	ketoreductase activity
A	0047017	molecular_function	prostaglandin F synthase activity
A	0047020	molecular_function	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
A	0047023	molecular_function	androsterone dehydrogenase [NAD(P)+] activity
A	0047024	molecular_function	5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity
A	0047035	molecular_function	testosterone dehydrogenase (NAD+) activity
A	0047045	molecular_function	testosterone dehydrogenase (NADP+) activity
A	0047086	molecular_function	ketosteroid monooxygenase activity
A	0047115	molecular_function	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
A	0047743	molecular_function	chlordecone reductase activity
A	0047787	molecular_function	Delta4-3-oxosteroid 5beta-reductase activity
A	0072582	molecular_function	17-beta-hydroxysteroid dehydrogenase (NADP+) activity
A	0140169	molecular_function	3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	binding site for residue 2BA A 401

Chain	Residue
A	TYR24
A	GLN270
A	SER271
A	GLU276
A	GLU279
A	ASN280
A	HOH506
A	HOH536
A	HOH538
A	HOH539
A	HOH547
A	TYR55
A	HOH552
A	HOH554
A	HOH608
A	HOH643
A	HOH660
A	HOH771
A	TYR216
A	GLY217
A	ALA218
A	LEU219
A	GLY220
A	THR221
A	ALA253

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Functional Information from PROSITE/UniProt

site_id	PS00062
Number of Residues	18
Details	ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. LeeckdaglVKSIGVSNF

Chain	Residue	Details
A	LEU151-PHE168

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site_id	PS00798
Number of Residues	18
Details	ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHVDTAyayqvEeeIG

Chain	Residue	Details
A	GLY45-GLY62

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Lowers pKa of active site Tyr","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of putative reductase (NP_038806.2) from Mus musculus at 1.18 A resolution.","authoringGroup":["Joint center for structural genomics (JCSG)"]}}]}

Chain

Residue

Details

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