5UUP

Human Bfl-1 covalently cross-linked to an electrophilic variant of a Bfl-1-specific selected peptide

5UUP の概要

• エントリーDOI: 10.2210/pdb5uup/pdb
• 関連するPDBエントリー: 5UUK 5UUL 5UUM
• 分子名称: Bcl-2-related protein A1, Bfl-1-specific selected peptide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: apoptosis regulatory proteins, electrophile, protein binding, protein structure, proto-oncogene, specificity, bcl2a1, bcl2 related protein a1, peptide inhibitor, apoptosis
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20149.79

構造登録者

Jenson, J.M.,Grant, R.A.,Keating, A.E. (登録日: 2017-02-17, 公開日: 2017-06-21, 最終更新日: 2023-10-04)

• 主引用文献: Jenson, J.M.,Ryan, J.A.,Grant, R.A.,Letai, A.,Keating, A.E.; Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.; Elife, 6:-, 2017; PubMed: 28594323; DOI: 10.7554/eLife.25541

実験手法

X-RAY DIFFRACTION (1.726 Å)