5US1

Crystal structure of aminoglycoside acetyltransferase AAC(2')-Ia in complex with N2'-acetylgentamicin C1A and coenzyme A

5US1 の概要

• エントリーDOI: 10.2210/pdb5us1/pdb
• 関連するPDBエントリー: 6C0C
• 分子名称: Aminoglycoside 2'-N-acetyltransferase, (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-(acetylamino)-6-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranoside, D(-)-TARTARIC ACID, ... (7 entities in total)
• 機能のキーワード: gnat, gcn5-n-acetyltransferase, acetyltransferase, aminoglycoside, gentamicin, coenzyme a, acetylcoenzyme a antibiotic resistance, structural genomics, center for structural genomics of infectious diseases, csgid, national institute of allergy and infectious diseases, niaid, transferase
• 由来する生物種: Providencia stuartii
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 263334.07

構造登録者

Stogios, P.J.,Evdokimova, E.,Xu, Z.,Wawrzak, Z.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2017-02-13, 公開日: 2017-03-15, 最終更新日: 2023-10-04)

• 主引用文献: Cox, G.,Ejim, L.,Stogios, P.J.,Koteva, K.,Bordeleau, E.,Evdokimova, E.,Sieron, A.O.,Savchenko, A.,Serio, A.W.,Krause, K.M.,Wright, G.D.; Plazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.; ACS Infect Dis, 4:980-987, 2018; PubMed: 29634241; DOI: 10.1021/acsinfecdis.8b00001

実験手法

X-RAY DIFFRACTION (2.48 Å)