5US1
Crystal structure of aminoglycoside acetyltransferase AAC(2')-Ia in complex with N2'-acetylgentamicin C1A and coenzyme A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Aminoglycoside 2'-N-acetyltransferase | polymer | 189 | 21189.9 | 12 | UniProt (Q52424) Pfam (PF13527) | Providencia stuartii | AAC(2')-Ia |
| 2 | AA, EA, GA, M, O... (I, K, L, A, B...) | (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-(acetylamino)-6-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranoside | non-polymer | 491.6 | 10 | Chemie (8MM) | |||
| 3 | DA, N, S, W, Z (J, A, D, F, H) | D(-)-TARTARIC ACID | non-polymer | 150.1 | 5 | Chemie (TAR) | |||
| 4 | P (C) | ACETYL COENZYME *A | non-polymer | 809.6 | 1 | Chemie (ACO) | |||
| 5 | CA, FA, Q (I, K, C) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | BA, HA, U (I, L, E) | COENZYME A | non-polymer | 767.5 | 3 | Chemie (COA) | |||
| 7 | IA, JA, KA, LA, MA... (A, B, C, D, E...) | water | water | 18.0 | 579 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 1 - 178 (UniProt: Q52424)
| PDB | External Database | Details |
|---|---|---|
| Gly -10 | - | expression tag |
| Leu -9 | - | expression tag |
| Val -8 | - | expression tag |
| Pro -7 | - | expression tag |
| Arg -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Ser -4 | - | expression tag |
| His -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 254279.4 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 9054.7 | |
| All* | Total formula weight | 263334.1 |
