5US1
Crystal structure of aminoglycoside acetyltransferase AAC(2')-Ia in complex with N2'-acetylgentamicin C1A and coenzyme A
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
A | 0046677 | biological_process | response to antibiotic |
A | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
B | 0046677 | biological_process | response to antibiotic |
B | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
C | 0016746 | molecular_function | acyltransferase activity |
C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
C | 0046677 | biological_process | response to antibiotic |
C | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
D | 0016746 | molecular_function | acyltransferase activity |
D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
D | 0046677 | biological_process | response to antibiotic |
D | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
E | 0016746 | molecular_function | acyltransferase activity |
E | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
E | 0046677 | biological_process | response to antibiotic |
E | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
F | 0016746 | molecular_function | acyltransferase activity |
F | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
F | 0046677 | biological_process | response to antibiotic |
F | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
G | 0016746 | molecular_function | acyltransferase activity |
G | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
G | 0046677 | biological_process | response to antibiotic |
G | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
H | 0016746 | molecular_function | acyltransferase activity |
H | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
H | 0046677 | biological_process | response to antibiotic |
H | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
I | 0016746 | molecular_function | acyltransferase activity |
I | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
I | 0046677 | biological_process | response to antibiotic |
I | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
J | 0016746 | molecular_function | acyltransferase activity |
J | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
J | 0046677 | biological_process | response to antibiotic |
J | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
K | 0016746 | molecular_function | acyltransferase activity |
K | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
K | 0046677 | biological_process | response to antibiotic |
K | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
L | 0016746 | molecular_function | acyltransferase activity |
L | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
L | 0046677 | biological_process | response to antibiotic |
L | 0047921 | molecular_function | aminoglycoside 2'-N-acetyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | binding site for residue 8MM A 201 |
Chain | Residue |
A | ASP37 |
A | GLU149 |
A | ASP176 |
A | TRP178 |
A | HOH334 |
A | GLU79 |
A | ALA80 |
A | MET81 |
A | SER114 |
A | SER116 |
A | ASP117 |
A | TYR123 |
A | GLU148 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue TAR A 202 |
Chain | Residue |
A | ARG88 |
A | GLN90 |
A | GLY91 |
A | ILE92 |
A | GLY93 |
A | ARG94 |
A | LEU122 |
A | HOH312 |
site_id | AC3 |
Number of Residues | 12 |
Details | binding site for residue 8MM B 400 |
Chain | Residue |
B | ASP32 |
B | ASP37 |
B | ALA80 |
B | MET81 |
B | SER114 |
B | ALA115 |
B | SER116 |
B | ASP117 |
B | TYR123 |
B | GLU149 |
B | TRP178 |
B | HOH512 |
site_id | AC4 |
Number of Residues | 16 |
Details | binding site for residue ACO C 201 |
Chain | Residue |
C | ALA80 |
C | MET81 |
C | VAL82 |
C | VAL83 |
C | ARG88 |
C | ARG89 |
C | GLN90 |
C | GLY91 |
C | GLY93 |
C | ARG94 |
C | SER114 |
C | TYR123 |
C | HOH302 |
C | HOH303 |
G | TYR22 |
G | ASP23 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue GOL C 202 |
Chain | Residue |
C | ARG6 |
C | GLU17 |
C | PHE50 |
C | GLN53 |
site_id | AC6 |
Number of Residues | 11 |
Details | binding site for residue 8MM D 201 |
Chain | Residue |
D | PHE33 |
D | ASP37 |
D | ALA80 |
D | MET81 |
D | SER114 |
D | SER116 |
D | TYR123 |
D | GLU148 |
D | GLU149 |
D | TRP178 |
D | HOH319 |
site_id | AC7 |
Number of Residues | 7 |
Details | binding site for residue TAR D 202 |
Chain | Residue |
D | VAL83 |
D | ARG88 |
D | ARG89 |
D | GLN90 |
D | GLY91 |
D | GLY93 |
D | ARG94 |
site_id | AC8 |
Number of Residues | 13 |
Details | binding site for residue 8MM E 201 |
Chain | Residue |
E | ASP37 |
E | ALA80 |
E | MET81 |
E | SER114 |
E | SER116 |
E | ASP117 |
E | TYR123 |
E | GLU148 |
E | GLU149 |
E | ASP176 |
E | TRP178 |
E | COA202 |
E | HOH323 |
site_id | AC9 |
Number of Residues | 20 |
Details | binding site for residue COA E 202 |
Chain | Residue |
E | 8MM201 |
E | HOH302 |
E | HOH317 |
E | HOH321 |
J | GLN129 |
B | TYR22 |
B | ASP23 |
E | PHE29 |
E | MET81 |
E | VAL82 |
E | VAL83 |
E | ARG88 |
E | ARG89 |
E | GLN90 |
E | GLY91 |
E | GLY93 |
E | ARG94 |
E | SER116 |
E | LYS121 |
E | TYR123 |
site_id | AD1 |
Number of Residues | 10 |
Details | binding site for residue 8MM F 201 |
Chain | Residue |
F | ASP32 |
F | ASP37 |
F | MET81 |
F | SER114 |
F | SER116 |
F | GLU148 |
F | GLU149 |
F | ASP176 |
F | TRP178 |
F | HOH312 |
site_id | AD2 |
Number of Residues | 10 |
Details | binding site for residue TAR F 202 |
Chain | Residue |
F | VAL83 |
F | TYR87 |
F | ARG88 |
F | ARG89 |
F | GLN90 |
F | GLY91 |
F | ILE92 |
F | GLY93 |
F | ARG94 |
F | LEU122 |
site_id | AD3 |
Number of Residues | 11 |
Details | binding site for residue 8MM G 400 |
Chain | Residue |
G | ASP32 |
G | ASP37 |
G | ALA80 |
G | MET81 |
G | SER114 |
G | SER116 |
G | TYR123 |
G | GLU149 |
G | ASP176 |
G | TRP178 |
G | HOH502 |
site_id | AD4 |
Number of Residues | 9 |
Details | binding site for residue 8MM H 201 |
Chain | Residue |
H | ASP37 |
H | VAL78 |
H | ALA80 |
H | MET81 |
H | SER114 |
H | SER116 |
H | TYR123 |
H | GLU149 |
H | TRP178 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue TAR H 202 |
Chain | Residue |
H | GLY91 |
H | ILE92 |
H | GLY93 |
H | LEU122 |
site_id | AD6 |
Number of Residues | 14 |
Details | binding site for residue 8MM I 201 |
Chain | Residue |
I | ASP37 |
I | VAL78 |
I | GLU79 |
I | ALA80 |
I | MET81 |
I | SER114 |
I | SER116 |
I | ASP117 |
I | TYR123 |
I | GLU149 |
I | ASP176 |
I | TRP178 |
I | COA202 |
I | HOH322 |
site_id | AD7 |
Number of Residues | 15 |
Details | binding site for residue COA I 202 |
Chain | Residue |
I | GLY28 |
I | PHE29 |
I | MET81 |
I | VAL82 |
I | VAL83 |
I | ARG88 |
I | ARG89 |
I | GLY91 |
I | GLY93 |
I | ARG94 |
I | SER116 |
I | LYS121 |
I | TYR123 |
I | 8MM201 |
I | HOH302 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue GOL I 203 |
Chain | Residue |
I | LEU98 |
I | ASN101 |
I | VAL126 |
I | HOH301 |
site_id | AD9 |
Number of Residues | 5 |
Details | binding site for residue TAR J 201 |
Chain | Residue |
J | VAL83 |
J | GLY91 |
J | GLY93 |
J | ARG94 |
J | LEU122 |
site_id | AE1 |
Number of Residues | 14 |
Details | binding site for residue 8MM K 201 |
Chain | Residue |
K | ASP32 |
K | ASP37 |
K | VAL78 |
K | GLU79 |
K | ALA80 |
K | MET81 |
K | SER114 |
K | SER116 |
K | ASP117 |
K | TYR123 |
K | GLU149 |
K | TRP178 |
K | HOH306 |
K | HOH324 |
site_id | AE2 |
Number of Residues | 5 |
Details | binding site for residue GOL K 202 |
Chain | Residue |
I | LYS134 |
K | ARG94 |
K | GLN95 |
K | LEU98 |
K | HOH312 |
site_id | AE3 |
Number of Residues | 8 |
Details | binding site for residue 8MM L 201 |
Chain | Residue |
L | ASP37 |
L | ALA80 |
L | MET81 |
L | SER114 |
L | ALA115 |
L | GLU149 |
L | TRP178 |
L | COA202 |
site_id | AE4 |
Number of Residues | 17 |
Details | binding site for residue COA L 202 |
Chain | Residue |
L | GLY28 |
L | PHE29 |
L | MET81 |
L | VAL82 |
L | VAL83 |
L | ARG88 |
L | ARG89 |
L | GLN90 |
L | GLY91 |
L | ILE92 |
L | GLY93 |
L | ARG94 |
L | ALA115 |
L | SER116 |
L | LYS121 |
L | TYR123 |
L | 8MM201 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 72 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P9WQG9 |
Chain | Residue | Details |
A | ASP32 | |
B | ARG88 | |
B | SER114 | |
B | GLU148 | |
C | ASP32 | |
C | GLU79 | |
C | MET81 | |
C | ARG88 | |
C | SER114 | |
C | GLU148 | |
D | ASP32 | |
A | GLU79 | |
D | GLU79 | |
D | MET81 | |
D | ARG88 | |
D | SER114 | |
D | GLU148 | |
E | ASP32 | |
E | GLU79 | |
E | MET81 | |
E | ARG88 | |
E | SER114 | |
A | MET81 | |
E | GLU148 | |
F | ASP32 | |
F | GLU79 | |
F | MET81 | |
F | ARG88 | |
F | SER114 | |
F | GLU148 | |
G | ASP32 | |
G | GLU79 | |
G | MET81 | |
A | ARG88 | |
G | ARG88 | |
G | SER114 | |
G | GLU148 | |
H | ASP32 | |
H | GLU79 | |
H | MET81 | |
H | ARG88 | |
H | SER114 | |
H | GLU148 | |
I | ASP32 | |
A | SER114 | |
I | GLU79 | |
I | MET81 | |
I | ARG88 | |
I | SER114 | |
I | GLU148 | |
J | ASP32 | |
J | GLU79 | |
J | MET81 | |
J | ARG88 | |
J | SER114 | |
A | GLU148 | |
J | GLU148 | |
K | ASP32 | |
K | GLU79 | |
K | MET81 | |
K | ARG88 | |
K | SER114 | |
K | GLU148 | |
L | ASP32 | |
L | GLU79 | |
L | MET81 | |
B | ASP32 | |
L | ARG88 | |
L | SER114 | |
L | GLU148 | |
B | GLU79 | |
B | MET81 |