5UR7

Crystal structure of engineered CCL20 disulfide locked dimer

Summary for 5UR7

• Entry DOI: 10.2210/pdb5ur7/pdb
• Descriptor: C-C motif chemokine 20, ACETATE ION, ISOPROPYL ALCOHOL, ... (4 entities in total)
• Functional Keywords: ccl20, chemokine, macrophage inflammatory protein-3 alpha, mip3-alpha, chemotaxis, psoriasis, locked dimer, cytokine, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 16474.58

Authors

Getschman, A.E.,Peterson, F.C.,Volkman, B.F. (deposition date: 2017-02-09, release date: 2017-11-22, Last modification date: 2023-10-04)

• Primary citation: Getschman, A.E.,Imai, Y.,Larsen, O.,Peterson, F.C.,Wu, X.,Rosenkilde, M.M.,Hwang, S.T.,Volkman, B.F.; Protein engineering of the chemokine CCL20 prevents psoriasiform dermatitis in an IL-23-dependent murine model.; Proc. Natl. Acad. Sci. U.S.A., 114:12460-12465, 2017; PubMed: 29109267; DOI: 10.1073/pnas.1704958114

Experimental method

X-RAY DIFFRACTION (2.0004 Å)