5UR7

Crystal structure of engineered CCL20 disulfide locked dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006935	biological_process	chemotaxis
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0007165	biological_process	signal transduction
A	0007267	biological_process	cell-cell signaling
A	0008009	molecular_function	chemokine activity
A	0019722	biological_process	calcium-mediated signaling
A	0031731	molecular_function	CCR6 chemokine receptor binding
A	0042742	biological_process	defense response to bacterium
A	0060326	biological_process	cell chemotaxis
A	0072678	biological_process	T cell migration
A	0072679	biological_process	thymocyte migration
A	2000406	biological_process	positive regulation of T cell migration
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006935	biological_process	chemotaxis
B	0006954	biological_process	inflammatory response
B	0006955	biological_process	immune response
B	0007165	biological_process	signal transduction
B	0007267	biological_process	cell-cell signaling
B	0008009	molecular_function	chemokine activity
B	0019722	biological_process	calcium-mediated signaling
B	0031731	molecular_function	CCR6 chemokine receptor binding
B	0042742	biological_process	defense response to bacterium
B	0060326	biological_process	cell chemotaxis
B	0072678	biological_process	T cell migration
B	0072679	biological_process	thymocyte migration
B	2000406	biological_process	positive regulation of T cell migration

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue ACT A 101

Chain	Residue
A	ASP5

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site_id	AC2
Number of Residues	3
Details	binding site for residue ACT A 102

Chain	Residue
A	TYR58
B	THR54
B	ARG61

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site_id	AC3
Number of Residues	3
Details	binding site for residue ACT A 103

Chain	Residue
A	ILE14
A	LEU15
A	HIS16

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site_id	AC4
Number of Residues	1
Details	binding site for residue IPA A 104

Chain	Residue
A	HOH229

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site_id	AC5
Number of Residues	4
Details	binding site for residue ACT B 101

Chain	Residue
B	ASP12
B	GLN53
B	TRP55
A	HIS16

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Functional Information from PROSITE/UniProt

site_id	PS00472
Number of Residues	44
Details	SMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCLgytdri..LhpkfIvgFtrqlanegCdin.AIIFhtkkklsv.CA

Chain	Residue	Details
A	CYS6-ALA49

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