5UIH

structure of DHFR with bound phenformin and NADP

Summary for 5UIH

• Entry DOI: 10.2210/pdb5uih/pdb
• Related: 5UII 5UIO 5UIP
• Descriptor: Dihydrofolate reductase, N-(2-phenylethyl)imidodicarbonimidic diamide, SODIUM ION, ... (7 entities in total)
• Functional Keywords: dhfr, phenformin, nadp, oxidoreductase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 20188.28

Authors

Pedersen, L.C.,London, R.E. (deposition date: 2017-01-14, release date: 2017-11-22, Last modification date: 2023-10-04)

• Primary citation: Gabel, S.A.,Duff, M.R.,Pedersen, L.C.,DeRose, E.F.,Krahn, J.M.,Howell, E.E.,London, R.E.; A Structural Basis for Biguanide Activity.; Biochemistry, 56:4786-4798, 2017; PubMed: 28766937; DOI: 10.1021/acs.biochem.7b00619

Experimental method