5UE2

proMMP-7 with heparin octasaccharide bridging between domains

Summary for 5UE2

• Entry DOI: 10.2210/pdb5ue2/pdb
• Related: 2MZE
• NMR Information: BMRB: 25485
• Descriptor: Matrilysin, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: glycan complex with protein, enzyme complex with heparin oligosaccharide, zymogen, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 30128.01

Authors

Fulcher, Y.G.,Prior, S.H.,Linhardt, R.J.,Van Doren, S.R. (deposition date: 2016-12-29, release date: 2017-07-19, Last modification date: 2023-06-14)

• Primary citation: Fulcher, Y.G.,Prior, S.H.,Masuko, S.,Li, L.,Pu, D.,Zhang, F.,Linhardt, R.J.,Van Doren, S.R.; Glycan Activation of a Sheddase: Electrostatic Recognition between Heparin and proMMP-7.; Structure, 25:1100-1110.e5, 2017; PubMed: 28648610; DOI: 10.1016/j.str.2017.05.019

Experimental method

SOLUTION NMR