5UC4

Hsp90b N-terminal domain with inhibitors

Summary for 5UC4

DescriptorHeat shock protein HSP 90-beta, 5-Hydroxy-4-(isoindoline-2-carbonyl)-2-isopropylbenzaldehyde, GLYCEROL, ... (5 entities in total)
Functional Keywordshsp90, inhibitor, chaperone-inhibitor complex, chaperone/inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm  P08238
Total number of polymer chains4
Total molecular weight100065.11
Authors
Deng, J.,Peng, S.,Balch, M.,Matts, R. (deposition date: 2016-12-21, release date: 2018-01-17, Last modification date: 2018-03-07)
Primary citation
Khandelwal, A.,Kent, C.N.,Balch, M.,Peng, S.,Mishra, S.J.,Deng, J.,Day, V.W.,Liu, W.,Subramanian, C.,Cohen, M.,Holzbeierlein, J.M.,Matts, R.,Blagg, B.S.J.
Structure-guided design of an Hsp90 beta N-terminal isoform-selective inhibitor.
Nat Commun, 9:425-425, 2018
PubMed: 29382832 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-017-02013-1
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.05 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.208600.1%5.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution