5UC1
Structural Analysis of Glucocorticoid Receptor beta Ligand Binding Domain Complexed with Glucocorticoid Antagonist RU-486: Implication of Helix 12 in Antagonism
Summary for 5UC1
Entry DOI | 10.2210/pdb5uc1/pdb |
Related | 5UC3 |
Descriptor | Glucocorticoid receptor, 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ... (7 entities in total) |
Functional Keywords | nuclear receptor, hormone receptor |
Biological source | Heterocephalus glaber (Naked mole rat) |
Total number of polymer chains | 2 |
Total formula weight | 55276.61 |
Authors | Pedersen, L.C.,Min, J. (deposition date: 2016-12-21, release date: 2017-12-27, Last modification date: 2023-10-04) |
Primary citation | Min, J.,Perera, L.,Krahn, J.M.,Jewell, C.M.,Moon, A.F.,Cidlowski, J.A.,Pedersen, L.C. Probing Dominant Negative Behavior of Glucocorticoid Receptor beta through a Hybrid Structural and Biochemical Approach. Mol. Cell. Biol., 2018 Cited by PubMed: 29437838DOI: 10.1128/MCB.00453-17 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.351 Å) |
Structure validation
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