5UC1
Structural Analysis of Glucocorticoid Receptor beta Ligand Binding Domain Complexed with Glucocorticoid Antagonist RU-486: Implication of Helix 12 in Antagonism
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glucocorticoid receptor | polymer | 222 | 25634.7 | 2 | Pfam (PF00104) UniProt (by SIFTS) (P04150) UniProt (by SIFTS) (G5AQS2) | Heterocephalus glaber (Naked mole rat) | |
| 2 | C, K (A, B) | 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE | non-polymer | 429.6 | 2 | Chemie (486) PubChem (16394559) PubChem (20651195) PubChem (25260940) PubChem (40785059) PubChem (55245) PubChem (16758830) PubChem (18649237) PubChem (1756360) PubChem (49800048) PubChem (26339468) PubChem (374394) PubChem (73897308) PubChem (70407138) PubChem (4196) PubChem (6604445) PubChem (124300838) PubChem (124404360) PubChem (9910521) PubChem (6426861) PubChem (6569219) PubChem (6604870) PubChem (6712024) PubChem (7048587) PubChem (7048709) PubChem (7048710) PubChem (11743390) PubChem (10387949) PubChem (124338910) PubChem (13080184) PubChem (13080185) PubChem (13080187) PubChem (130205874) PubChem (131632911) PubChem (133269675) PubChem (133688789) PubChem (138113540) PubChem (139025155) PubChem (145874921) PubChem (170056603) PubChem (170130266) | |||
| 3 | D, E, L, M (A, B) | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 4 | Chemie (CPS) PubChem (16396400) PubChem (18397788) PubChem (177530666) PubChem (24883538) PubChem (50987450) PubChem (51028881) PubChem (51028882) PubChem (53393728) PubChem (44120060) PubChem (58528211) PubChem (44450441) PubChem (53229977) PubChem (457060) PubChem (3659871) PubChem (107670) PubChem (71774074) PubChem (90488808) PubChem (91746229) PubChem (91809267) PubChem (102565428) PubChem (122361936) PubChem (122362044) PubChem (9895216) PubChem (10371606) PubChem (131632459) PubChem (133645855) PubChem (137704711) PubChem (146159681) | |||
| 4 | F, G, N, O (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) PubChem (312) | |||
| 5 | H, P (A, B) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 2 | Chemie (MPD) | |||
| 6 | I, J, Q, R, S (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 7 | T, U (A, B) | water | water | 18.0 | 19 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51269.4 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 4007.2 | |
| All* | Total formula weight | 55276.6 |
