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5UC1

Structural Analysis of Glucocorticoid Receptor beta Ligand Binding Domain Complexed with Glucocorticoid Antagonist RU-486: Implication of Helix 12 in Antagonism

Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue 486 A 801
ChainResidue
ALEU559
B486801
AASN560
AGLY563
AGLN566
AVAL567
AMET600
AARG607
APHE619
AHOH906

site_idAC2
Number of Residues6
Detailsbinding site for residue CPS A 802
ChainResidue
ATHR551
ATRP553
BILE568
BGLN593
BTRP596
BCL804

site_idAC3
Number of Residues8
Detailsbinding site for residue CPS A 803
ChainResidue
AGLN641
APHE644
ASER720
AGLU723
AASN724
BTYR634
BASP637
BGLN638

site_idAC4
Number of Residues4
Detailsbinding site for residue CL A 804
ChainResidue
AGLN593
BTHR552
BPRO633
BCPS802

site_idAC5
Number of Residues3
Detailsbinding site for residue CL A 805
ChainResidue
ASER678
AGLU680
ALEU681

site_idAC6
Number of Residues1
Detailsbinding site for residue EDO A 807
ChainResidue
ALYS663

site_idAC7
Number of Residues9
Detailsbinding site for residue 486 B 801
ChainResidue
A486801
BLEU559
BASN560
BGLY564
BGLN566
BMET600
BARG607
BPHE619
BMET642

site_idAC8
Number of Residues5
Detailsbinding site for residue CPS B 802
ChainResidue
AMET589
AGLN593
ACL804
BTHR551
BTRP553

site_idAC9
Number of Residues9
Detailsbinding site for residue CPS B 803
ChainResidue
ATYR634
AASP637
AGLN638
BGLN641
BPHE644
BSER720
BMET721
BGLU723
BASN724

site_idAD1
Number of Residues4
Detailsbinding site for residue CL B 804
ChainResidue
ATHR551
ATHR552
ACPS802
BGLN593

site_idAD2
Number of Residues3
Detailsbinding site for residue CL B 805
ChainResidue
BSER678
BGLU680
BLEU681

site_idAD3
Number of Residues1
Detailsbinding site for residue EDO B 807
ChainResidue
BLYS663

site_idAD4
Number of Residues1
Detailsbinding site for residue EDO B 808
ChainResidue
BGLY694

site_idAD5
Number of Residues6
Detailsbinding site for residue EDO B 809
ChainResidue
BGLU648
BARG651
BGLN713
BLYS716
BLEU717
BSER720

227561

PDB entries from 2024-11-20

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