5U86

Structure of the Aquifex aeolicus LpxC/LPC-069 complex

Summary for 5U86

Entry DOI	10.2210/pdb5u86/pdb
Descriptor	UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide, ... (7 entities in total)
Functional Keywords	lpxc lipid a antibiotic lps, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Aquifex aeolicus (strain VF5)
Total number of polymer chains	1
Total formula weight	32417.52
Authors	Najeeb, J.,Lee, C.-J.,Zhou, P. (deposition date: 2016-12-13, release date: 2017-08-09, Last modification date: 2023-10-04)
Primary citation	Lemaitre, N.,Liang, X.,Najeeb, J.,Lee, C.J.,Titecat, M.,Leteurtre, E.,Simonet, M.,Toone, E.J.,Zhou, P.,Sebbane, F. Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC. MBio, 8:-, 2017 Cited by PubMed: 28743813 DOI: 10.1128/mBio.00674-17 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation