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5U6B

Structure of the Axl kinase domain in complex with a macrocyclic inhibitor

Summary for 5U6B
Entry DOI10.2210/pdb5u6b/pdb
Related5U6C
DescriptorTyrosine-protein kinase receptor UFO, (10R)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1H-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one (2 entities in total)
Functional Keywordskinase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane ; Single-pass type I membrane protein : P30530
Total number of polymer chains4
Total formula weight141323.51
Authors
Gajiwala, K.S.,Grodsky, N. (deposition date: 2016-12-07, release date: 2017-07-26, Last modification date: 2024-03-06)
Primary citationGajiwala, K.S.,Grodsky, N.,Bolanos, B.,Feng, J.,Ferre, R.,Timofeevski, S.,Xu, M.,Murray, B.W.,Johnson, T.W.,Stewart, A.
The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase.
J. Biol. Chem., 292:15705-15716, 2017
Cited by
PubMed: 28724631
DOI: 10.1074/jbc.M116.771485
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.84 Å)
Structure validation

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