5U6B
Structure of the Axl kinase domain in complex with a macrocyclic inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tyrosine-protein kinase receptor UFO | polymer | 307 | 34870.0 | 4 | UniProt (P30530) Pfam (PF07714) | Homo sapiens (Human) | AXL oncogene |
| 2 | E, F, G, H (A, B, C, D) | (10R)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1H-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one | non-polymer | 460.9 | 4 | Chemie (7YS) |
Sequence modifications
A, B, C, D: 514 - 818 (UniProt: P30530)
| PDB | External Database | Details |
|---|---|---|
| Gly 512 | - | expression tag |
| Ser 513 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 139480.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1843.6 | |
| All* | Total formula weight | 141323.5 |
