5U1E
Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with the kanamycin B
Summary for 5U1E
| Entry DOI | 10.2210/pdb5u1e/pdb |
| Related | 5U0N 5U0T 5U18 5U19 5U1I |
| Descriptor | Putative gentamicin methyltransferase, (1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL 2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total) |
| Functional Keywords | gentamicin methyltransferase sah kanamycin b, transferase |
| Biological source | Micromonospora echinospora |
| Total number of polymer chains | 1 |
| Total formula weight | 38263.66 |
| Authors | Bury, P.,Huang, F.,Leadlay, P.,Dias, M.V.B. (deposition date: 2016-11-28, release date: 2017-11-01, Last modification date: 2023-10-04) |
| Primary citation | Bury, P.D.S.,Huang, F.,Li, S.,Sun, Y.,Leadlay, P.F.,Dias, M.V.B. Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis. ACS Chem. Biol., 12:2779-2787, 2017 Cited by PubMed: 28876898DOI: 10.1021/acschembio.7b00466 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.213 Å) |
Structure validation
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