5U19

Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with (1R,2S,3S,4R,6R)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside

5U19 の概要

• エントリーDOI: 10.2210/pdb5u19/pdb
• 関連するPDBエントリー: 5U0N 5U0T 5U18 5U1E 5U1I
• 分子名称: Putative gentamicin methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: gentamicin methyltransferase, transferase
• 由来する生物種: Micromonospora echinospora
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38286.98

構造登録者

Bury, P.,Huang, F.,Leadlay, P.,Dias, M.V.B. (登録日: 2016-11-28, 公開日: 2017-11-01, 最終更新日: 2023-10-04)

• 主引用文献: Bury, P.D.S.,Huang, F.,Li, S.,Sun, Y.,Leadlay, P.F.,Dias, M.V.B.; Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis.; ACS Chem. Biol., 12:2779-2787, 2017; PubMed: 28876898; DOI: 10.1021/acschembio.7b00466

実験手法

X-RAY DIFFRACTION (1.902 Å)