5U18

Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with the Geneticin

Summary for 5U18

• Entry DOI: 10.2210/pdb5u18/pdb
• Related: 5U0N 5U0T 5U19 5U1E 5U1I
• Descriptor: N-3'' methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, GENETICIN, ... (4 entities in total)
• Functional Keywords: gentamicin methyltransferase sah g418, transferase
• Biological source: Micromonospora echinospora
• Total number of polymer chains: 1
• Total formula weight: 36105.34

Authors

Bury, P.,Huang, F.,Leadlay, P.,Dias, M.V.B. (deposition date: 2016-11-28, release date: 2017-11-01, Last modification date: 2024-03-06)

• Primary citation: Bury, P.D.S.,Huang, F.,Li, S.,Sun, Y.,Leadlay, P.F.,Dias, M.V.B.; Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis.; ACS Chem. Biol., 12:2779-2787, 2017; PubMed: 28876898; DOI: 10.1021/acschembio.7b00466

Experimental method

X-RAY DIFFRACTION (2.195 Å)