5U18

Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with the Geneticin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0008168	molecular_function	methyltransferase activity
A	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
A	0032259	biological_process	methylation
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue SAH A 401

Chain	Residue
A	ASP107
A	MET180
A	ASN194
A	PRO196
A	LEU207
A	LEU208
A	ILE214
A	GET402
A	HOH521
A	HOH522
A	HOH531
A	GLY131
A	HOH544
A	HOH555
A	HOH559
A	HOH576
A	CYS132
A	GLY133
A	VAL136
A	ASP152
A	VAL153
A	GLY178
A	ASP179

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site_id	AC2
Number of Residues	22
Details	binding site for residue GET A 402

Chain	Residue
A	ASP95
A	VAL96
A	GLU98
A	GLN101
A	ASP107
A	TRP110
A	GLU111
A	ARG176
A	ASN194
A	SER195
A	PRO196
A	THR197
A	ASN198
A	LEU208
A	ASN235
A	ARG281
A	SAH401
A	HOH501
A	HOH510
A	HOH518
A	HOH557
A	HOH574

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