5U19
Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with (1R,2S,3S,4R,6R)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue SAH A 401 |
| Chain | Residue |
| A | ASP107 |
| A | MET180 |
| A | ASN194 |
| A | LEU207 |
| A | LEU208 |
| A | ILE214 |
| A | 827403 |
| A | HOH511 |
| A | HOH537 |
| A | HOH543 |
| A | HOH549 |
| A | GLY131 |
| A | HOH550 |
| A | HOH560 |
| A | HOH601 |
| A | CYS132 |
| A | GLY133 |
| A | LEU137 |
| A | ASP152 |
| A | VAL153 |
| A | GLY178 |
| A | ASP179 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | GLU98 |
| A | ASP206 |
| A | HOH508 |
| A | HOH584 |
| A | HOH605 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | binding site for residue 827 A 403 |
| Chain | Residue |
| A | ASP95 |
| A | VAL96 |
| A | GLU98 |
| A | GLN101 |
| A | ASP107 |
| A | TRP110 |
| A | GLU111 |
| A | THR174 |
| A | PHE175 |
| A | ARG176 |
| A | ASN194 |
| A | SER195 |
| A | PRO196 |
| A | THR197 |
| A | ASN198 |
| A | LEU208 |
| A | ASN235 |
| A | ARG281 |
| A | SAH401 |
| A | HOH558 |
| A | HOH589 |
