5U19

Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with (1R,2S,3S,4R,6R)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0008168	molecular_function	methyltransferase activity
A	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue SAH A 401

Chain	Residue
A	ASP107
A	MET180
A	ASN194
A	LEU207
A	LEU208
A	ILE214
A	827403
A	HOH511
A	HOH537
A	HOH543
A	HOH549
A	GLY131
A	HOH550
A	HOH560
A	HOH601
A	CYS132
A	GLY133
A	LEU137
A	ASP152
A	VAL153
A	GLY178
A	ASP179

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 402

Chain	Residue
A	GLU98
A	ASP206
A	HOH508
A	HOH584
A	HOH605

---

site_id	AC3
Number of Residues	21
Details	binding site for residue 827 A 403

Chain	Residue
A	ASP95
A	VAL96
A	GLU98
A	GLN101
A	ASP107
A	TRP110
A	GLU111
A	THR174
A	PHE175
A	ARG176
A	ASN194
A	SER195
A	PRO196
A	THR197
A	ASN198
A	LEU208
A	ASN235
A	ARG281
A	SAH401
A	HOH558
A	HOH589

---