5U19
Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with (1R,2S,3S,4R,6R)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
A | 0032259 | biological_process | methylation |
A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 22 |
Details | binding site for residue SAH A 401 |
Chain | Residue |
A | ASP107 |
A | MET180 |
A | ASN194 |
A | LEU207 |
A | LEU208 |
A | ILE214 |
A | 827403 |
A | HOH511 |
A | HOH537 |
A | HOH543 |
A | HOH549 |
A | GLY131 |
A | HOH550 |
A | HOH560 |
A | HOH601 |
A | CYS132 |
A | GLY133 |
A | LEU137 |
A | ASP152 |
A | VAL153 |
A | GLY178 |
A | ASP179 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MG A 402 |
Chain | Residue |
A | GLU98 |
A | ASP206 |
A | HOH508 |
A | HOH584 |
A | HOH605 |
site_id | AC3 |
Number of Residues | 21 |
Details | binding site for residue 827 A 403 |
Chain | Residue |
A | ASP95 |
A | VAL96 |
A | GLU98 |
A | GLN101 |
A | ASP107 |
A | TRP110 |
A | GLU111 |
A | THR174 |
A | PHE175 |
A | ARG176 |
A | ASN194 |
A | SER195 |
A | PRO196 |
A | THR197 |
A | ASN198 |
A | LEU208 |
A | ASN235 |
A | ARG281 |
A | SAH401 |
A | HOH558 |
A | HOH589 |