5TXF

Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in a closed conformation

Summary for 5TXF

Entry DOI	10.2210/pdb5txf/pdb
Descriptor	Phosphatidylcholine-sterol acyltransferase, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	acyltransferase, cholesterol, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	195467.34
Authors	Manthei, K.A.,Glukhova, A.,Tesmer, J.J.G. (deposition date: 2016-11-16, release date: 2017-10-25, Last modification date: 2023-10-04)
Primary citation	Manthei, K.A.,Ahn, J.,Glukhova, A.,Yuan, W.,Larkin, C.,Manett, T.D.,Chang, L.,Shayman, J.A.,Axley, M.J.,Schwendeman, A.,Tesmer, J.J.G. A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I. J. Biol. Chem., 292:20313-20327, 2017 Cited by PubMed: 29030428 DOI: 10.1074/jbc.M117.802736 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation