Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5TXF

Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in a closed conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003847	molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity
A	0004607	molecular_function	phosphatidylcholine-sterol O-acyltransferase activity
A	0004623	molecular_function	phospholipase A2 activity
A	0004771	molecular_function	sterol ester esterase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006629	biological_process	lipid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0006656	biological_process	phosphatidylcholine biosynthetic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008374	molecular_function	O-acyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0030301	biological_process	cholesterol transport
A	0034186	molecular_function	apolipoprotein A-I binding
A	0034364	cellular_component	high-density lipoprotein particle
A	0034372	biological_process	very-low-density lipoprotein particle remodeling
A	0034375	biological_process	high-density lipoprotein particle remodeling
A	0034435	biological_process	obsolete cholesterol esterification
A	0042157	biological_process	lipoprotein metabolic process
A	0042158	biological_process	lipoprotein biosynthetic process
A	0042632	biological_process	cholesterol homeostasis
A	0043691	biological_process	reverse cholesterol transport
A	0046222	biological_process	aflatoxin metabolic process
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046688	biological_process	response to copper ion
A	0047179	molecular_function	platelet-activating factor acetyltransferase activity
A	0051384	biological_process	response to glucocorticoid
A	0070062	cellular_component	extracellular exosome
A	0090107	biological_process	regulation of high-density lipoprotein particle assembly
B	0003847	molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity
B	0004607	molecular_function	phosphatidylcholine-sterol O-acyltransferase activity
B	0004623	molecular_function	phospholipase A2 activity
B	0004771	molecular_function	sterol ester esterase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006629	biological_process	lipid metabolic process
B	0006644	biological_process	phospholipid metabolic process
B	0006656	biological_process	phosphatidylcholine biosynthetic process
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0008374	molecular_function	O-acyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0030301	biological_process	cholesterol transport
B	0034186	molecular_function	apolipoprotein A-I binding
B	0034364	cellular_component	high-density lipoprotein particle
B	0034372	biological_process	very-low-density lipoprotein particle remodeling
B	0034375	biological_process	high-density lipoprotein particle remodeling
B	0034435	biological_process	obsolete cholesterol esterification
B	0042157	biological_process	lipoprotein metabolic process
B	0042158	biological_process	lipoprotein biosynthetic process
B	0042632	biological_process	cholesterol homeostasis
B	0043691	biological_process	reverse cholesterol transport
B	0046222	biological_process	aflatoxin metabolic process
B	0046470	biological_process	phosphatidylcholine metabolic process
B	0046688	biological_process	response to copper ion
B	0047179	molecular_function	platelet-activating factor acetyltransferase activity
B	0051384	biological_process	response to glucocorticoid
B	0070062	cellular_component	extracellular exosome
B	0090107	biological_process	regulation of high-density lipoprotein particle assembly
C	0003847	molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity
C	0004607	molecular_function	phosphatidylcholine-sterol O-acyltransferase activity
C	0004623	molecular_function	phospholipase A2 activity
C	0004771	molecular_function	sterol ester esterase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006629	biological_process	lipid metabolic process
C	0006644	biological_process	phospholipid metabolic process
C	0006656	biological_process	phosphatidylcholine biosynthetic process
C	0008202	biological_process	steroid metabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0008374	molecular_function	O-acyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016787	molecular_function	hydrolase activity
C	0030301	biological_process	cholesterol transport
C	0034186	molecular_function	apolipoprotein A-I binding
C	0034364	cellular_component	high-density lipoprotein particle
C	0034372	biological_process	very-low-density lipoprotein particle remodeling
C	0034375	biological_process	high-density lipoprotein particle remodeling
C	0034435	biological_process	obsolete cholesterol esterification
C	0042157	biological_process	lipoprotein metabolic process
C	0042158	biological_process	lipoprotein biosynthetic process
C	0042632	biological_process	cholesterol homeostasis
C	0043691	biological_process	reverse cholesterol transport
C	0046222	biological_process	aflatoxin metabolic process
C	0046470	biological_process	phosphatidylcholine metabolic process
C	0046688	biological_process	response to copper ion
C	0047179	molecular_function	platelet-activating factor acetyltransferase activity
C	0051384	biological_process	response to glucocorticoid
C	0070062	cellular_component	extracellular exosome
C	0090107	biological_process	regulation of high-density lipoprotein particle assembly
D	0003847	molecular_function	1-alkyl-2-acetylglycerophosphocholine esterase activity
D	0004607	molecular_function	phosphatidylcholine-sterol O-acyltransferase activity
D	0004623	molecular_function	phospholipase A2 activity
D	0004771	molecular_function	sterol ester esterase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006629	biological_process	lipid metabolic process
D	0006644	biological_process	phospholipid metabolic process
D	0006656	biological_process	phosphatidylcholine biosynthetic process
D	0008202	biological_process	steroid metabolic process
D	0008203	biological_process	cholesterol metabolic process
D	0008374	molecular_function	O-acyltransferase activity
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016787	molecular_function	hydrolase activity
D	0030301	biological_process	cholesterol transport
D	0034186	molecular_function	apolipoprotein A-I binding
D	0034364	cellular_component	high-density lipoprotein particle
D	0034372	biological_process	very-low-density lipoprotein particle remodeling
D	0034375	biological_process	high-density lipoprotein particle remodeling
D	0034435	biological_process	obsolete cholesterol esterification
D	0042157	biological_process	lipoprotein metabolic process
D	0042158	biological_process	lipoprotein biosynthetic process
D	0042632	biological_process	cholesterol homeostasis
D	0043691	biological_process	reverse cholesterol transport
D	0046222	biological_process	aflatoxin metabolic process
D	0046470	biological_process	phosphatidylcholine metabolic process
D	0046688	biological_process	response to copper ion
D	0047179	molecular_function	platelet-activating factor acetyltransferase activity
D	0051384	biological_process	response to glucocorticoid
D	0070062	cellular_component	extracellular exosome
D	0090107	biological_process	regulation of high-density lipoprotein particle assembly

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VFLIGHSLGC

Chain	Residue	Details
A	VAL175-CYS184

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"26195816","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"26195816","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Determinant for substrate specificity","evidences":[{"source":"PubMed","id":"14636062","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7613477","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"26195816","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7613477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4X96","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26195816","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7613477","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4X96","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)