5TXF

Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in a closed conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Phosphatidylcholine-sterol acyltransferase	polymer	422	47957.5	4	UniProt (P04180) Pfam (PF02450) In PDB	Homo sapiens (Human)	Lecithin-cholesterol acyltransferase,Phospholipid-cholesterol acyltransferase
2	E, G, I, J	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	4	In PDB GlyTouCan (G15407YE)
3	F, H	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	A, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5		water	water		18.0	14	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 416 (UniProt: P04180)

PDB	External Database	Details
His 417	-	expression tag
His 418	-	expression tag
His 419	-	expression tag
His 420	-	expression tag
His 421	-	expression tag
His 422	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	191830.0
Branched	Number of molecules	6
	Total formula weight	3195.0
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	195467.3

*Water molecules are not included.