5TT2
Inactive conformation of engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
Summary for 5TT2
Entry DOI | 10.2210/pdb5tt2/pdb |
Descriptor | Cystathionine gamma-lyase, SULFATE ION (2 entities in total) |
Functional Keywords | engineered protein, methioninase, inactive form, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 93604.46 |
Authors | |
Primary citation | Yan, W.,Stone, E.,Zhang, Y.J. Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site. Biochemistry, 56:876-885, 2017 Cited by PubMed: 28106980DOI: 10.1021/acs.biochem.6b01172 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.949 Å) |
Structure validation
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