5TIU

Crystal structure of SYK kinase domain with inhibitor

Summary for 5TIU

Entry DOI	10.2210/pdb5tiu/pdb
Descriptor	Tyrosine-protein kinase SYK, 5-{[(2S)-2-aminopropyl]amino}-3-(1H-indol-2-yl)pyrazine-2-carboxamide (3 entities in total)
Functional Keywords	carboxamide spleen tyrosine kinase (syk), transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane : P43405
Total number of polymer chains	1
Total formula weight	34194.36
Authors	Ellis, J.M.,Altman, M.D.,Cash, B.,Haidle, A.M.,Kubiak, R.L.,Maddess, M.L.,Yan, Y.,Northrup, A.B. (deposition date: 2016-10-03, release date: 2017-01-11, Last modification date: 2024-04-03)
Primary citation	Ellis, J.M.,Altman, M.D.,Cash, B.,Haidle, A.M.,Kubiak, R.L.,Maddess, M.L.,Yan, Y.,Northrup, A.B. Carboxamide Spleen Tyrosine Kinase (Syk) Inhibitors: Leveraging Ground State Interactions To Accelerate Optimization. ACS Med Chem Lett, 7:1151-1155, 2016 Cited by PubMed: 27994755 DOI: 10.1021/acsmedchemlett.6b00353 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.49 Å)

Structure validation