5TIU

Crystal structure of SYK kinase domain with inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tyrosine-protein kinase SYK	polymer	291	33884.0	1	UniProt (P43405) Pfam (PF07714) In PDB	Homo sapiens (Human)	Spleen tyrosine kinase,p72-Syk
2	A	5-{[(2S)-2-aminopropyl]amino}-3-(1H-indol-2-yl)pyrazine-2-carboxamide	non-polymer		310.4	1	Chemie (7CU)
3		water	water		18.0	248	Chemie (HOH)

Sequence modifications

A: 356 - 635 (UniProt: P43405)

PDB	External Database	Details
Met 353	-	initiating methionine
Ala 354	-	expression tag
Leu 355	-	expression tag
Glu 636	-	expression tag
Gly 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33884.0
Non-Polymers*	Number of molecules	1
	Total formula weight	310.4
All*	Total formula weight	34194.4

*Water molecules are not included.