5TCG

Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate-bound form

5TCG の概要

• エントリーDOI: 10.2210/pdb5tcg/pdb
• 関連するPDBエントリー: 5TCF 5TCH 5TCI 5TCJ
• 分子名称: Tryptophan synthase alpha chain, Tryptophan synthase beta chain, MALONATE ION, ... (7 entities in total)
• 機能のキーワード: plp, heterotetramer, amino acid biosynthesis, substrate channeling, allostery, structural genomics, center for structural genomics of infectious diseases, csgid, lyase
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 291684.02

構造登録者

Michalska, K.,Maltseva, N.,Jedrzejczak, R.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2016-09-15, 公開日: 2017-05-31, 最終更新日: 2024-05-22)

• 主引用文献: Wellington, S.,Nag, P.P.,Michalska, K.,Johnston, S.E.,Jedrzejczak, R.P.,Kaushik, V.K.,Clatworthy, A.E.,Siddiqi, N.,McCarren, P.,Bajrami, B.,Maltseva, N.I.,Combs, S.,Fisher, S.L.,Joachimiak, A.,Schreiber, S.L.,Hung, D.T.; A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.; Nat. Chem. Biol., 13:943-950, 2017; PubMed: 28671682; DOI: 10.1038/nchembio.2420

実験手法

X-RAY DIFFRACTION (2.4 Å)