5TCG

Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate-bound form

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, G, E, C)	Tryptophan synthase alpha chain	polymer	276	28579.4	4	UniProt (P9WFY1) Pfam (PF00290)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
2	B, D, F, H (B, H, F, D)	Tryptophan synthase beta chain	polymer	410	43334.6	4	UniProt (P9WFX9) Pfam (PF00291)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
3	FA, I, OA, S (E, A, C, G)	MALONATE ION	non-polymer		102.0	4	Chemie (MLI)
4	AA, BA, CA, DA, EA... (H, A, F, B, C...)	FORMIC ACID	non-polymer		46.0	25	Chemie (FMT)
5	GA, K, QA, W (F, B, D, H)	2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID	non-polymer		318.2	4	Chemie (P1T)
6	HA, IA, JA, L, M... (F, B, D, H)	CESIUM ION	non-polymer		132.9	9	Chemie (CS)
7	AB, BB, CB, DB, EB... (G, H, E, F, C...)	water	water		18.0	890	Chemie (HOH)

Sequence modifications

A, G, E, C: 1 - 270 (UniProt: P9WFY1)

PDB	External Database	Details
His 271	-	expression tag
His 272	-	expression tag
His 273	-	expression tag
His 274	-	expression tag
His 275	-	expression tag
His 276	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	287656.2
Non-Polymers*	Number of molecules	42
	Total formula weight	4027.8
All*	Total formula weight	291684.0

*Water molecules are not included.