5TCG
Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate-bound form
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000162 | biological_process | tryptophan biosynthetic process |
A | 0004834 | molecular_function | tryptophan synthase activity |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006568 | biological_process | tryptophan metabolic process |
A | 0016829 | molecular_function | lyase activity |
B | 0000162 | biological_process | tryptophan biosynthetic process |
B | 0004834 | molecular_function | tryptophan synthase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006568 | biological_process | tryptophan metabolic process |
B | 0016829 | molecular_function | lyase activity |
B | 1901605 | biological_process | alpha-amino acid metabolic process |
C | 0000162 | biological_process | tryptophan biosynthetic process |
C | 0004834 | molecular_function | tryptophan synthase activity |
C | 0005829 | cellular_component | cytosol |
C | 0005886 | cellular_component | plasma membrane |
C | 0006568 | biological_process | tryptophan metabolic process |
C | 0016829 | molecular_function | lyase activity |
D | 0000162 | biological_process | tryptophan biosynthetic process |
D | 0004834 | molecular_function | tryptophan synthase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006568 | biological_process | tryptophan metabolic process |
D | 0016829 | molecular_function | lyase activity |
D | 1901605 | biological_process | alpha-amino acid metabolic process |
E | 0000162 | biological_process | tryptophan biosynthetic process |
E | 0004834 | molecular_function | tryptophan synthase activity |
E | 0005829 | cellular_component | cytosol |
E | 0005886 | cellular_component | plasma membrane |
E | 0006568 | biological_process | tryptophan metabolic process |
E | 0016829 | molecular_function | lyase activity |
F | 0000162 | biological_process | tryptophan biosynthetic process |
F | 0004834 | molecular_function | tryptophan synthase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0006568 | biological_process | tryptophan metabolic process |
F | 0016829 | molecular_function | lyase activity |
F | 1901605 | biological_process | alpha-amino acid metabolic process |
G | 0000162 | biological_process | tryptophan biosynthetic process |
G | 0004834 | molecular_function | tryptophan synthase activity |
G | 0005829 | cellular_component | cytosol |
G | 0005886 | cellular_component | plasma membrane |
G | 0006568 | biological_process | tryptophan metabolic process |
G | 0016829 | molecular_function | lyase activity |
H | 0000162 | biological_process | tryptophan biosynthetic process |
H | 0004834 | molecular_function | tryptophan synthase activity |
H | 0005737 | cellular_component | cytoplasm |
H | 0006568 | biological_process | tryptophan metabolic process |
H | 0016829 | molecular_function | lyase activity |
H | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue MLI A 301 |
Chain | Residue |
A | TYR181 |
A | GLY217 |
A | LEU218 |
A | GLY219 |
A | ILE237 |
A | GLY239 |
A | SER240 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue FMT A 302 |
Chain | Residue |
A | TYR181 |
A | ILE237 |
A | TYR30 |
A | GLU57 |
site_id | AC3 |
Number of Residues | 20 |
Details | binding site for residue P1T B 501 |
Chain | Residue |
B | HIS100 |
B | LYS101 |
B | THR124 |
B | GLY125 |
B | ALA126 |
B | GLY127 |
B | GLN128 |
B | HIS129 |
B | THR204 |
B | CYS244 |
B | GLY246 |
B | GLY247 |
B | GLY248 |
B | SER249 |
B | ASN250 |
B | GLY317 |
B | GLU364 |
B | SER390 |
B | GLY391 |
B | HOH639 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue CS B 502 |
Chain | Residue |
B | GLY246 |
B | ALA282 |
B | THR284 |
B | TYR320 |
B | GLY322 |
B | HOH644 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue CS B 503 |
Chain | Residue |
B | LYS402 |
B | TRP403 |
H | LYS402 |
H | TRP403 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue FMT B 504 |
Chain | Residue |
B | LYS47 |
B | GLU48 |
B | ARG114 |
B | HOH693 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue FMT B 505 |
Chain | Residue |
B | ARG355 |
B | PHE404 |
D | LEU165 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue FMT B 506 |
Chain | Residue |
B | GLN80 |
B | HOH730 |
F | ARG119 |
F | VAL145 |
site_id | AC9 |
Number of Residues | 2 |
Details | binding site for residue FMT B 507 |
Chain | Residue |
B | LEU165 |
D | ARG355 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue FMT B 508 |
Chain | Residue |
B | GLN80 |
B | SER84 |
F | ASP190 |
F | ASN194 |
F | HOH619 |
site_id | AD2 |
Number of Residues | 8 |
Details | binding site for residue MLI G 301 |
Chain | Residue |
G | TYR181 |
G | GLY217 |
G | LEU218 |
G | GLY219 |
G | GLY239 |
G | SER240 |
G | FMT303 |
G | HOH415 |
site_id | AD3 |
Number of Residues | 1 |
Details | binding site for residue FMT G 302 |
Chain | Residue |
G | ARG223 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue FMT G 303 |
Chain | Residue |
G | GLU57 |
G | MET106 |
G | TYR181 |
G | ILE237 |
G | MLI301 |
site_id | AD5 |
Number of Residues | 3 |
Details | binding site for residue FMT G 304 |
Chain | Residue |
C | ARG85 |
G | HIS152 |
G | HOH424 |
site_id | AD6 |
Number of Residues | 19 |
Details | binding site for residue P1T H 501 |
Chain | Residue |
H | HIS100 |
H | LYS101 |
H | THR124 |
H | GLY125 |
H | ALA126 |
H | GLY127 |
H | GLN128 |
H | HIS129 |
H | THR204 |
H | CYS244 |
H | GLY246 |
H | GLY247 |
H | GLY248 |
H | SER249 |
H | ASN250 |
H | GLY317 |
H | GLU364 |
H | SER390 |
H | HOH657 |
site_id | AD7 |
Number of Residues | 6 |
Details | binding site for residue CS H 502 |
Chain | Residue |
H | GLY322 |
H | HOH621 |
H | GLY246 |
H | ALA282 |
H | THR284 |
H | TYR320 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue FMT H 503 |
Chain | Residue |
D | ARG119 |
H | ARG77 |
H | GLN80 |
H | HOH715 |
site_id | AD9 |
Number of Residues | 4 |
Details | binding site for residue FMT H 504 |
Chain | Residue |
H | LYS47 |
H | GLU48 |
H | ARG114 |
H | HOH647 |
site_id | AE1 |
Number of Residues | 2 |
Details | binding site for residue FMT H 505 |
Chain | Residue |
H | HOH605 |
H | HOH654 |
site_id | AE2 |
Number of Residues | 3 |
Details | binding site for residue FMT H 506 |
Chain | Residue |
F | LEU165 |
H | ARG355 |
H | PHE404 |
site_id | AE3 |
Number of Residues | 2 |
Details | binding site for residue FMT H 507 |
Chain | Residue |
F | ARG355 |
H | LEU165 |
site_id | AE4 |
Number of Residues | 2 |
Details | binding site for residue FMT H 508 |
Chain | Residue |
D | ASN194 |
H | SER84 |
site_id | AE5 |
Number of Residues | 3 |
Details | binding site for residue FMT H 509 |
Chain | Residue |
H | GLY20 |
H | GLY24 |
H | GLU332 |
site_id | AE6 |
Number of Residues | 6 |
Details | binding site for residue MLI E 301 |
Chain | Residue |
E | TYR181 |
E | GLY217 |
E | LEU218 |
E | GLY219 |
E | GLY239 |
E | SER240 |
site_id | AE7 |
Number of Residues | 20 |
Details | binding site for residue P1T F 501 |
Chain | Residue |
F | HIS100 |
F | LYS101 |
F | THR124 |
F | GLY125 |
F | ALA126 |
F | GLY127 |
F | GLN128 |
F | HIS129 |
F | THR204 |
F | CYS244 |
F | GLY246 |
F | GLY247 |
F | GLY248 |
F | SER249 |
F | ASN250 |
F | GLY317 |
F | GLU364 |
F | SER390 |
F | GLY391 |
F | HOH638 |
site_id | AE8 |
Number of Residues | 6 |
Details | binding site for residue CS F 502 |
Chain | Residue |
F | GLY246 |
F | ALA282 |
F | THR284 |
F | TYR320 |
F | GLY322 |
F | HOH627 |
site_id | AE9 |
Number of Residues | 1 |
Details | binding site for residue CS F 503 |
Chain | Residue |
F | LEU142 |
site_id | AF1 |
Number of Residues | 6 |
Details | binding site for residue CS F 504 |
Chain | Residue |
F | GLY67 |
F | PRO69 |
F | HOH735 |
H | GLY67 |
H | PRO69 |
H | HOH780 |
site_id | AF2 |
Number of Residues | 7 |
Details | binding site for residue FMT F 505 |
Chain | Residue |
D | GLY141 |
D | LEU142 |
D | ASP143 |
D | CS503 |
F | GLY141 |
F | LEU142 |
F | ASP143 |
site_id | AF3 |
Number of Residues | 2 |
Details | binding site for residue FMT F 506 |
Chain | Residue |
F | LYS47 |
F | GLU48 |
site_id | AF4 |
Number of Residues | 1 |
Details | binding site for residue FMT F 507 |
Chain | Residue |
F | SER23 |
site_id | AF5 |
Number of Residues | 5 |
Details | binding site for residue FMT F 508 |
Chain | Residue |
F | ARG280 |
F | HIS312 |
F | SER313 |
F | ILE314 |
F | ASP343 |
site_id | AF6 |
Number of Residues | 8 |
Details | binding site for residue MLI C 301 |
Chain | Residue |
C | TYR181 |
C | GLY217 |
C | LEU218 |
C | GLY219 |
C | ILE237 |
C | GLY239 |
C | SER240 |
C | FMT302 |
site_id | AF7 |
Number of Residues | 6 |
Details | binding site for residue FMT C 302 |
Chain | Residue |
C | TYR30 |
C | GLU57 |
C | ILE72 |
C | MET106 |
C | TYR181 |
C | MLI301 |
site_id | AF8 |
Number of Residues | 21 |
Details | binding site for residue P1T D 501 |
Chain | Residue |
D | HIS100 |
D | LYS101 |
D | THR124 |
D | GLY125 |
D | ALA126 |
D | GLY127 |
D | GLN128 |
D | HIS129 |
D | THR204 |
D | CYS244 |
D | GLY246 |
D | GLY247 |
D | GLY248 |
D | SER249 |
D | ASN250 |
D | GLY317 |
D | GLU364 |
D | SER390 |
D | GLY391 |
D | HOH630 |
D | HOH678 |
site_id | AF9 |
Number of Residues | 6 |
Details | binding site for residue CS D 502 |
Chain | Residue |
D | GLY246 |
D | ALA282 |
D | THR284 |
D | TYR320 |
D | GLY322 |
D | HOH692 |
site_id | AG1 |
Number of Residues | 3 |
Details | binding site for residue CS D 503 |
Chain | Residue |
D | LEU142 |
F | FMT505 |
F | HOH704 |
site_id | AG2 |
Number of Residues | 6 |
Details | binding site for residue CS D 504 |
Chain | Residue |
B | GLY67 |
B | PRO69 |
B | HOH756 |
B | HOH758 |
D | GLY67 |
D | PRO69 |
site_id | AG3 |
Number of Residues | 1 |
Details | binding site for residue FMT D 505 |
Chain | Residue |
D | SER23 |
site_id | AG4 |
Number of Residues | 3 |
Details | binding site for residue FMT D 506 |
Chain | Residue |
D | LYS47 |
D | GLU48 |
D | HOH657 |
site_id | AG5 |
Number of Residues | 3 |
Details | binding site for residue FMT D 507 |
Chain | Residue |
D | HIS312 |
D | SER313 |
D | ASP319 |
site_id | AG6 |
Number of Residues | 1 |
Details | binding site for residue FMT D 508 |
Chain | Residue |
D | GLU40 |
Functional Information from PROSITE/UniProt
site_id | PS00167 |
Number of Residues | 14 |
Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. IEVGvPYSDPGMDG |
Chain | Residue | Details |
A | ILE56-GLY69 |
site_id | PS00168 |
Number of Residues | 15 |
Details | TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LnHtGSHKiNnvLgQ |
Chain | Residue | Details |
B | LEU94-GLN108 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000255|HAMAP-Rule:MF_00133 |
Chain | Residue | Details |
B | HIS100 | |
H | HIS100 | |
F | HIS100 | |
D | HIS100 | |
E | GLU57 | |
E | ASP68 | |
C | GLU57 | |
C | ASP68 |