Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5T8P

Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to benzoxepin compound 2

Summary for 5T8P
Entry DOI10.2210/pdb5t8p/pdb
DescriptorMitogen-activated protein kinase kinase kinase 14, 6,7-dihydrothieno[4,5]oxepino[1,2-~{c}]pyridine-2-carboxamide, SULFATE ION, ... (4 entities in total)
Functional Keywordsprotein serine/threonine kinase, nf-kappab, map3k14, transferase
Biological sourceMus musculus (Mouse)
Cellular locationCytoplasm: Q9WUL6
Total number of polymer chains2
Total formula weight77963.72
Authors
Smith, M.A.,McEwan, P.A. (deposition date: 2016-09-08, release date: 2017-01-11, Last modification date: 2017-02-08)
Primary citationCastanedo, G.M.,Blaquiere, N.,Beresini, M.,Bravo, B.,Brightbill, H.,Chen, J.,Cui, H.F.,Eigenbrot, C.,Everett, C.,Feng, J.,Godemann, R.,Gogol, E.,Hymowitz, S.,Johnson, A.,Kayagaki, N.,Kohli, P.B.,Knuppel, K.,Kraemer, J.,Kruger, S.,Loke, P.,McEwan, P.,Montalbetti, C.,Roberts, D.A.,Smith, M.,Steinbacher, S.,Sujatha-Bhaskar, S.,Takahashi, R.,Wang, X.,Wu, L.C.,Zhang, Y.,Staben, S.T.
Structure-Based Design of Tricyclic NF-kappa B Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).
J. Med. Chem., 60:627-640, 2017
Cited by
PubMed: 28005357
DOI: 10.1021/acs.jmedchem.6b01363
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.32 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon