5SYM
Cocrystal structure of the human acyl protein thioesterase 1 with an isoform-selective inhibitor, ML348
Summary for 5SYM
Entry DOI | 10.2210/pdb5sym/pdb |
Related | 5SYN |
Descriptor | Acyl-protein thioesterase 1, N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[4-(furan-2-carbonyl)piperazin-1-yl]acetamide, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | hydrolase, inhibitor, thioesterase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 50792.96 |
Authors | Stuckey, J.A.,Labby, K.J.,Meagher, J.L.,Won, S.J.,Martin, B.R. (deposition date: 2016-08-11, release date: 2016-10-26, Last modification date: 2023-10-04) |
Primary citation | Won, S.J.,Davda, D.,Labby, K.J.,Hwang, S.Y.,Pricer, R.,Majmudar, J.D.,Armacost, K.A.,Rodriguez, L.A.,Rodriguez, C.L.,Chong, F.S.,Torossian, K.A.,Palakurthi, J.,Hur, E.S.,Meagher, J.L.,Brooks, C.L.,Stuckey, J.A.,Martin, B.R. Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem. Biol., 11:3374-3382, 2016 Cited by PubMed: 27748579DOI: 10.1021/acschembio.6b00720 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
Download full validation report