5SX5
Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3 mutant S468R.
Summary for 5SX5
Entry DOI | 10.2210/pdb5sx5/pdb |
Related | 5SX4 |
Descriptor | Panitumumab Fab Light Chain, Panitumumab Fab Heavy Chain, Epidermal growth factor receptor, ... (8 entities in total) |
Functional Keywords | cetuximab, panitumumab, egfr, vectibix, erbitux, transferase-immune system complex, transferase/immune system |
Biological source | Homo sapiens More |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 6 |
Total formula weight | 141231.64 |
Authors | Sickmier, E.A. (deposition date: 2016-08-09, release date: 2016-10-05, Last modification date: 2023-10-04) |
Primary citation | Sickmier, E.A.,Kurzeja, R.J.,Michelsen, K.,Vazir, M.,Yang, E.,Tasker, A.S. The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance. Plos One, 11:e0163366-e0163366, 2016 Cited by PubMed: 27658254DOI: 10.1371/journal.pone.0163366 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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