5OSM

Cdk2(F80C, C177A) with covalent adduct at C80

Summary for 5OSM

Entry DOI	10.2210/pdb5osm/pdb
Related	5OO0 5OO1 5OO3 5OSJ
Descriptor	Cyclin-dependent kinase 2, methyl 1-propanoyl-3,4-dihydro-2~{H}-quinoline-6-carboxylate (3 entities in total)
Functional Keywords	covalent inhibitor, cysteine modification, kinase, allosteric inhibitor, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Total number of polymer chains	1
Total formula weight	34559.14
Authors	Craven, G.,Morgan, R.M.L.,Mann, D.J. (deposition date: 2017-08-17, release date: 2018-03-14, Last modification date: 2024-01-17)
Primary citation	Craven, G.B.,Affron, D.P.,Allen, C.E.,Matthies, S.,Greener, J.G.,Morgan, R.M.L.,Tate, E.W.,Armstrong, A.,Mann, D.J. High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery. Angew. Chem. Int. Ed. Engl., 57:5257-5261, 2018 Cited by PubMed: 29480525 DOI: 10.1002/anie.201711825 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation